Primary Supervisor
Primary Supervisor
Co-Supervisor
Senior Lecturer
I obtained my Masters from the University of Natal. I thereafter worked for 4 years as assistant researcher officer at the South African Sugar Experiment Station (Now South African Sugar Research Institute). During my appointment at SASRI, I investigated the interaction between sugarcane smut and host, sugarcane, using cDNA-AFLP. I then worked as a lecturer at the University of Johannesburg. In 2004, I was awarded the prestigious commonwealth Scholarship to undertake my PhD studies at the University of Dundee (based at the Scottish Crop Research Institute (SCRI) now The James Hutton Institute) under the supervision of Prof Paul Birch and Dr Ian Toth. During my PhD studies, I investigated host pathogen interaction between the soft rot pathogen Pectobacterium atrosepticum and its host potato).
I am currently the research group leader of bacterial genomics and host pathogen interactions. Our research has two major components. The first area of our research is towards understanding virulence mechanisms of soft rot pathogens (specifically Pectobacterium carotovorum subsp brasiliense) and how these bacteria interact within their major host potato. We are also interested in studying host defences in potato plants elicited by the soft rot pathogens. The second focus area is on root knot nematodes of potatoes. In this area of research we endeavored to better understand the threat posed by root knot nematodes to the potato industry through understanding the diversity and overall impact of RKN on potato production. We are funded mainly by the National Research Foundation (NRF), Potatoes South Africa (PSA) and NRF (THRIP), International Foundation for Science (IFS), Gauteng Department of Agriculture and Rural Development (GDARD) and various other funding bodies.
The group currently has 4 (2 main supervisor) PhD students and 4 MSc students. Some of the current projects include understanding host defence mechanisms in potato in a compatible vs incompatible interaction with P. c. brasiliense) and functional characterisation of major virulence genes of the same pathogen.
Chepsergon J, Moleleki LN. (2023) “Order from disordered”: Potential role of intrinsically disordered regions in phytopathogenic oomycete intracellular effector proteins. Current Opinion in Plant Biology 10.1016/j.pbi.2023.102402
Macharia TN, Duong TA, Moleleki LN. (2023) n silico secretome analyses of the polyphagous root-knot nematode Meloidogyne javanica: a resource for studying M. javanica secreted proteins. BMC Genomics 10.1186/s12864-023-09366-6
Chepsergon J, Lucy N Moleleki. (2023) Rhizosphere bacterial interactions and impact on plant health. Current Opinion in Microbiology 10.1016/j.mib.2023.102297
Jane Chepsergon, Celiwe Nxumalo, Brenda Salasini, Aquillah Kanzi, Lucy Moleleki. (2022) Short Linear Motifs (SLiMs) in “Core” RxLR effectors of Phytophthora parasitica var. nicotianae: A case of PpRxLR1 effector. Microbiology Spectrum 10.1128/spectrum.01774-21
Collins Kipngetich Tanui, Divine Yutefar Shyntum, Precious K. Sedibane, Daniel Bellieny-Rabelo, Lucy N. Moleleki. (2021) Pectobacterium brasiliense 1692 chemotactic responses and the role of methyl-accepting chemotactic proteins in ecological fitness. 10.3389/fpls.2021.650894
Jane Chepsergon, Thabiso E. Motaung, Lucy Novungayo Moleleki. (2021) “Core” RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?. Virulence 10.1080/21505594.2021.1948277
Chepsergon J, Motaung TE, Bellieny-Rabelo D, Moleleki LN. (2020) Organize, Don’t Agonize: Strategic Success of Phytophthora Species. Microorganisms 10.3390/microorganisms8060917
Shin G, Schacterle JK, Shyntum DY, Moleleki LN, Coutinho T, Sundin GW. (2019) Functional characterization of a global virulence regulator Hfq and identification of Hfq-dependent sRNAs in the plant pathogen Pantoea ananatis. Frontiers in Microbiology 10.3389/fmicb.2019.02075
Siphathele Sibanda, Stanford Kwenda, Collins K. Tanui, Divine Shyntum, Teresa Coutinho, Lucy Moleleki. (2018) Transcriptome profiling reveals the EanI/R quorum sensing regulon in Pantoea ananatis LMG 2665T. Genes 10.3390/genes9030148
Zwart L, Berger DK, Moleleki LN, Van der Merwe NA, Myburg AA, Naidoo S. (2017) Evidence for salicylic acid signalling and histological changes in the defence response of Eucalyptus grandis to Chrysoporthe austroafricana. Scientific Reports 10.1038/srep45402